JAMA reports possible link between Squamous Cell Carcinoma and HPV

HPV & Squamous Cell Carcinoma: JAMA reports 01/2016

HPV & Squamous Cell Carcinoma link: JAMA reports 01/2016

Changes in unknown primary squamous cell carcinoma of the head and neck at initial presentation in the era of HPV

Some interesting clinical trial report data has been surfacing recently regarding the correlation between HPV and squamous cell carcinoma.  JAMA Abstract Report 2016 Jan 14:1-7. doi: 10.1001/jamaoto. 2015.3228 sites the frequency of UPSCC has increased significantly in recent calendar periods, and most cases are HPV-positive. Patients with HPV-positive UPSCC tend to be male (91% vs 42.9%, P = .005) and are in the younger (56.1 vs 67.7 years, P = .002) age bracket.

JAMA Otolaryngology- Head & Neck Surgery, 01/29/2016 Motz K, et al.  The authors aim to determine the frequency of unknown primary squamous cell carcinoma (UPSCC) over time and to evaluate the proportion of the human papilloma virus (HPV)-positive UPSCCs.  The frequency of UPSCC has increased significantly in recent calendar periods, and most cases are HPV-positive.

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